diff --git a/app/src/main/java/org/mozilla/fenix/tabtray/FenixTabsAdapter.kt b/app/src/main/java/org/mozilla/fenix/tabtray/FenixTabsAdapter.kt
index 23a08374a..1610ffd91 100644
--- a/app/src/main/java/org/mozilla/fenix/tabtray/FenixTabsAdapter.kt
+++ b/app/src/main/java/org/mozilla/fenix/tabtray/FenixTabsAdapter.kt
@@ -6,6 +6,7 @@ package org.mozilla.fenix.tabtray
 
 import android.content.Context
 import android.view.LayoutInflater
+import mozilla.components.browser.tabstray.TabViewHolder
 import mozilla.components.browser.tabstray.TabsAdapter
 import mozilla.components.concept.tabstray.Tabs
 import mozilla.components.support.images.loader.ImageLoader
@@ -26,9 +27,17 @@ class FenixTabsAdapter(
     }
 ) {
     var onTabsUpdated: (() -> Unit)? = null
+    var tabCount = 0
 
     override fun updateTabs(tabs: Tabs) {
         super.updateTabs(tabs)
         onTabsUpdated?.invoke()
+        tabCount = tabs.list.size
+    }
+
+    override fun onBindViewHolder(holder: TabViewHolder, position: Int) {
+        super.onBindViewHolder(holder, position)
+        val newIndex = tabCount - position - 1
+        (holder as TabTrayViewHolder).updateAccessibilityRowIndex(holder.itemView, newIndex)
     }
 }
diff --git a/app/src/main/java/org/mozilla/fenix/tabtray/TabTrayView.kt b/app/src/main/java/org/mozilla/fenix/tabtray/TabTrayView.kt
index 5c5bc09c3..89863db6e 100644
--- a/app/src/main/java/org/mozilla/fenix/tabtray/TabTrayView.kt
+++ b/app/src/main/java/org/mozilla/fenix/tabtray/TabTrayView.kt
@@ -117,6 +117,9 @@ class TabTrayView(
             TabsTouchHelper(tray.tabsAdapter).attachToRecyclerView(tray)
             (tray.tabsAdapter as? FenixTabsAdapter)?.also { adapter ->
                 adapter.onTabsUpdated = {
+                    if (hasAccessibilityEnabled) {
+                        adapter.notifyDataSetChanged()
+                    }
                     if (!hasLoaded) {
                         hasLoaded = true
                         tray.layoutManager?.scrollToPosition(selectedBrowserTabIndex)
diff --git a/app/src/main/java/org/mozilla/fenix/tabtray/TabTrayViewHolder.kt b/app/src/main/java/org/mozilla/fenix/tabtray/TabTrayViewHolder.kt
index 2e4e5b770..697c0d423 100644
--- a/app/src/main/java/org/mozilla/fenix/tabtray/TabTrayViewHolder.kt
+++ b/app/src/main/java/org/mozilla/fenix/tabtray/TabTrayViewHolder.kt
@@ -5,6 +5,7 @@
 package org.mozilla.fenix.tabtray
 
 import android.view.View
+import android.view.accessibility.AccessibilityNodeInfo
 import android.widget.ImageButton
 import android.widget.TextView
 import androidx.annotation.VisibleForTesting
@@ -176,6 +177,28 @@ class TabTrayViewHolder(
             closeView.context.getString(R.string.close_tab_title, title)
     }
 
+    internal fun updateAccessibilityRowIndex(item: View, newIndex: Int) {
+        item.setAccessibilityDelegate(object : View.AccessibilityDelegate() {
+            override fun onInitializeAccessibilityNodeInfo(
+                host: View?,
+                info: AccessibilityNodeInfo?
+            ) {
+                super.onInitializeAccessibilityNodeInfo(host, info)
+                info?.let {
+                    val initialInfo = info.collectionItemInfo
+                    info.collectionItemInfo = AccessibilityNodeInfo.CollectionItemInfo.obtain(
+                        newIndex,
+                        initialInfo.rowSpan,
+                        initialInfo.columnIndex,
+                        initialInfo.columnSpan,
+                        false,
+                        initialInfo.isSelected
+                    )
+                }
+            }
+        })
+    }
+
     companion object {
         private const val PLAY_PAUSE_BUTTON_EXTRA_DPS = 24
     }